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Analysis of a form of oxidative DNA damage, 8-hydroxy-2-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

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Abstract A physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or good stress and is characterized by low to mild levels of oxidants involved in the regulation of various biochemical transformations such as carboxylation, hydroxylation, peroxidation, or modulation of signal transduction pathways such as Nuclear factor-B (NF-B), Mitogen-activated protein kinase (MAPK) cascade, phosphoinositide-3-kinase, nuclear factor erythroid 2related factor 2 (Nrf2) and other processes

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doi: 10.1186/s12943-023-01735-9 104 LiuMLiuJLiangZDaiKGanJWangQet al

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Li S, Zheng L, Zhang J, et al