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231 found that riluzole (Fig

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Excessive pyroptosis leads to rapid rupture of the plasma membrane and the excessive release of proinflammatory cytokines and chemokines, which results in neuroinflammation that triggers a cascade of secondary injuries culminating in neuronal death

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however, their clinical use is restricted due to strict contraindications, a limited treatment time frame, and severe adverse reactions, resulting in only a minority of patients reaping benefits from these interventions [5]

1991 Oct 2;69(15):722-4