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How AOD-9604 Avoids IGF-1 Stimulation Insulin-like growth factor 1 (IGF-1) is a hormone primarily produced in the liver in response to growth hormone receptor activation

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However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

Beyond a certain point, receptor saturation means diminishing returns

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