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The decreased level of ATP in the cytoplasm of nerve cells results in the opening of ATP-dependent potassium channels, which increases the membrane potential and causes a reduced response of cells to the stimuli 6

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Consumption of UPFs causes rapid spikes in blood glucose and insulin, triggering a pro-inflammatory cascade that exacerbates fatigue and widespread pain

Several pH-sensitive urease inhibitors of varying potency have been identified, and these include ammonia (the product of urease on its substrate), thiols, sulfite, fluoride, green tea-derived epigallocatechin gallate (EGCG), and heavy metals [222]

doi: 10.1002/em.10120