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Similar as in NC-derived melanoblasts, the cadherin-switch (from E-cadherin to N-cadherin) takes place in an important subset of melanomas and is induced by ZEB1, TWIST and SNAIL [7, 68, 69]

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Liver samples were stained with hematoxylin-eosin staining to determine fatty degradation and general morphology with picro sirius red staining to detect collagen and thus fibrosis as recently described [8]

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