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These changes include: (1) decreased bacterial diversity (101, 102), a decrease in short-chain fatty acid (SCFA)-producing bacteria from the Eubacteriaceae, Ruminococcaceae, and Lachnospiraceae families and several gut commensals with known immunomodulatory potential such as Faecalibacterium prausnitzii, Eubacterium rectale and bifidobacteria

(iii) testing encapsulated or acid-resistant delivery systems that ensure colon-specific release and viability under gastric conditions

Timing relative to exercise also matters

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It modulates brain insulin sensitivity, suppresses tau pathology, interacts with ER/ER to trigger neuroprotective PI3K/Akt cascades, and potentially reshapes gut microbiota to produce beneficial SCFAs

Other authors suggested that gliadin was able to bind the mono-sialic ganglioside 1 (GM1) or the receptors for the proinflammatory chemokine 3 (CXCR3) in mouse models, leading to the release of zonulin which in turn decreases electrical resistance of epithelial layers, finally resulting in increased epithelial permeability (139, 255)