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For instance, 25-hydroxycholesterol suppresses CYP51A1 mRNA levels in both human adrenocortical H295R and hepatocellular carcinoma HepG2 cells under cholesterol-deprived conditions [17]
Choline: Supports fat transport and liver function while helping maintain cellular integrity and brain health
Overall, these studies have reported mixed results, with a recent meta-analysis of 86 randomized controlled trials by Subramanian et al
Complicating this further: the regulatory picture shifted significantly between 2023 and 2025
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