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The pathology culminates in an immune-mediated rearrangement and destruction of the synovium in joints, causing a range of painful mobility-impairing symptoms

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However, the induction of the gut bacteria via prebiotics, probiotics, or antibiotics, and specific FMT-based studies, is an effective therapeutic or preventative measure to counteract behavioral and cognitive problems, and these may be useful to supplement the action of drugs for the management of brain disorders (121)

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