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In this cycle, it serves as a cofactor to allow conversion, so a deficiency of B12 or folate can interfere with the conversion and lead to a buildup of homocysteine 1

*Correspondence: Wen-Jun Gao, Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA e-mail: [email protected] This article was submitted to the journal Frontiers in Systems Neuroscience

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While generally well tolerated in research settings, certain reactions occur with enough regularity to warrant detailed examination

10.1016/j.lfs.2014.06.003 90 VijayvargiyaP.CamilleriM.ChedidV.MandawatA.ErwinP