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Pharmacogenomics 16 , 323332, (2015)

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Intriguingly, NADPH-dependent reductive stress stimulated glutaminolysis to generate -KG, which was then converted to succinyl-CoA by oxidative decarboxylation in the TCA cycle or to citrate via IDH2-mediated reductive carboxylation (23)

The crystallographic and regimen statistics are summarized in Supplemental Table S2

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Due to this, different routes for the administration of supplements may be necessary, such as: Oral replacement therapy is recommended to patients with asymptomatic, moderate illness who have no concerns about absorption or compliance