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The use of NAC in depression is supported by the presence of oxidative stress in depression, suggesting glutathione is a feasible treatment target [141]
Lermant A, Murdoch CE
The underlying relationship between high -PL production, biomass, mycelial viability, ATP accumulation, and pH shock was further explained by transcriptomic profiling at the early, middle, and late stages of -PL fermentation, which showed up-regulation of transcriptional regulatory genes involved in nitrogen metabolism, energy metabolism, electron respiratory chain, and redox homeostasis (Pan et al., 2019a)
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Glutathione does not work in a vacuum
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