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FIGURE 3 Another notable finding revealed by PET and NMR (nuclear magnetic resonance) spectroscopy analysis, is that in the brains of patients affected by ASD were found decreased glucose utilization and reduced ATP levels, further confirming mitochondrial dysfunction ( Other studies reported lactic acidosis and increased alanine levels, it is highly recognized that high concentrations of lactate can inhibit mitochondrial respiration and disbalance the redox equilibrium ( Alongside impairments in carbohydrate metabolism, evidence of reduced carnitine levels suggest a dysfunction in mitochondrial -oxidation, leading to accumulation of long-chain fatty acids and elevated markers of lipid elongation and desaturation ( These mitochondrial impairments not only compromise energy production but also act as pro-inflammatory stimuli, promoting chronic neuroinflammation through dysregulated mitochondrial signaling and innate immune response

Senescence is associated with TRPC3 downregulation, which increases mitochondrial Ca 2+ uptake, mitochondrial depolarization, and ROS production and alters mitochondrial metabolism, thereby promoting the protumourigenic effects of senescence [318]

2004;97(2):c41-c48

During digestion, this phospholipid layer provides a protective cover for vitamin C and, in addition to prolonged absorption, also allows easier penetration of vitamin C into cells

It should be adaptable for assessing both hydrophilic and lipophilic antioxidants and for using different radical sources

The effect of lysine was higher when compared with other positively charged amino acids, including ornithine, arginine, and -amino-caproic acid [106]