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J.LiX.WangZ.MoutonA
Damaged mitochondria increase the production of ROS and show metabolite imbalances with altered metabolic flux
Wang et al., 2021a
In a follow-up study, only one patient out of 62 treated with NAC within 10 hours developed severe liver injury as compared to a retrospective control group, which showed that 33 out of 57 patients (58%) developed severe liver injury after an acetaminophen overdose [14]
While its exact physiological mechanism remains under investigation, it is commonly used as a tool compound in sleep and stress-related neurobiology studies
