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37 Senescent fibroblasts promote degradation of the extracellular matrix (ECM) by secreting matrix metalloproteinase-1 (MMP1) and other proinflammatory factors, 38 ultimately leading to thinning of the epidermis and decreased barrier function, 39 while the selective removal of senescent cells leads to normalization of the ECM and a reduction in inflammation

Effect of in vitro enzymatic digestion on antioxidant activity of coffee melanoidins and fractions
