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10.1074/jbc.274.2.638 50 FangX.WangH.HanD.XieE.YangX.WeiJ.et al (2019)

This hyperglycemic model was previously validated by our lab through serial peripheral glucose monitoring, along with intra-tumoral glucose measurements ( 13 )

Many cases improve within 6-12 weeks with properly structured conservative treatment, including physical therapy, activity modification, and anti-inflammatory measures

Based on these findings, it is reasonable to hypothesize that 3-BrPA affects the metabolism of TNBC cells mainly by targeting the c-Myc/TXNIP axis, downregulating c-Myc and upregulating TXNIP, and this effect can only be fully displayed in cells with high c-Myc/low TXNIP

In addition, CHIR and forskolin further enhanced the culture

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