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Furthermore, any significant modifications to device design or manufacturing processes, particularly those influencing the drug constituent or primary mode of action, require reassessment by the designated Notified Body (NB), potentially triggering updated conformity assessments and scientific consultations [135, 136]

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Virology 210, 194201

Trempe JF, Sauve V, Grenier K, Seirafi M, Tang MY, Menade M, Al-Abdul-Wahid S, Krett J, Wong K, Kozlov G, Nagar B, Fon EA, Gehring K (2013) Structure of Parkin reveals mechanisms for ubiquitin ligase activation