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Abbreviations [ 18 F]FLT: Fluorothymidine F 18 ADC: Antibody drug conjugate AICARFTase: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase AML: Acute myeloid leukemia ATIC: inosine monophosphate cyclohydrolase BBB: Blood-brain barrier BLM: Bleomycin C1: one-carbon CAM: CAR T adaptor molecule CAR: Chimeric Antigen Receptor CFD: Cerebral Folate Deficiency CIC: human Capicua gene CRS: Cytokine release syndromes CSF: Cerebral spinal fluid DFS: Disease-free survival DOX: Doxorubicin FITC: Fluorescein isothiocyanate FR: Folate receptor GARFTase: Glycinamide ribonucleotide formyltransferase GPI: Glycosylphosphatidyl inositol IHC: Immunohistochemical JAK: Janus Kinase LRP2: Low Density Lipoprotein Receptor Related Protein 2 mAbs: Monoclonal antibodies MDR: Multidrug Resistance MTHFD: Methylene tetrahydrofolate dehydrogenase MTHFD2L: homologous to MTHFD2 MTHFR: Methylenetetrahydrofolate reductase MTX: Methotrexate MTX-PG: Methotrexate polyglutamates N4Py: N,N-bis (2-pyridylmethyl)-N-bis (2-pyridyl)-methylamine NIR: Near-infrared NMD: Nonsense-mediated mRNA decay OS: Overall survival PCFT: Proton-coupled folate transporter Pgp: P-glycoprotein PMX: Pemetrexed PtdCho: Phosphatidylcholine RA: Rheumatoid arthritis RFC: Reduced folate carrier SHMT: Serine hydroxymethyltransferase TAA: Tumor Associated Antigen TAMs: Tumor associated macrophages TCT: targeted chemotherapy or alternatively targeted conventional therapy THF: Tetrahydrofolate TS: Thymidylate synthase VDR: Vitamin D nuclear receptor References Ducker GS, Rabinowitz JD