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Description
Thirty-six patients from 31 families with molecularly confirmed spondylodysplastic EDS due to B4GALT7 -deficiency with a total of 13 different variants have been reported so far (Table 2) [8, 12,13,14,15,16,17,18,19,20,21,22,23,24]
The therapeutic window is longer than the pharmacokinetic half life because receptor occupancy and downstream signaling persist after plasma levels fall below detectable thresholds

Since B12 is water-soluble, your body excretes what it doesnt use, making it generally safe, even in higher doses [*]

Human trials are needed to verify advantages

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