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By inhibiting NNMT and preserving NAD, 5-Amino-1MQ indirectly boosts SIRT1 activity , leading to: Increased fat oxidation SIRT1 activates PGC-1 (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), a master regulator of mitochondrial biogenesis and fat metabolism

2012, 12 , 2452, DOI: 10.1021/nl3005385209A Close Look at Proteins: Submolecular Resolution of Two- and Three-Dimensionally Folded Cytochrome c at SurfacesDeng, Zhitao
