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The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose

Marfan syndrome [edit] TGF- signaling also likely plays a major role in the pathogenesis of Marfan syndrome, [84] a disease characterized by disproportionate height, arachnodactyly, ectopia lentis and heart complications such as mitral valve prolapse and aortic enlargement increasing the likelihood of aortic dissection

2013;305:C112338

10.1073/pnas.78.5.2777 [DOI] [PMC free article] [PubMed] [Google Scholar] 75.Via JR, Palacin M, Puertes IR, Hernandez R, Via J

Since the cellular synthesis of glutathione is ATP-dependent, decreased ETC activity also undermines glutathione synthesis, further exacerbating oxidative stress in a vicious cycle [8]