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EGCG was shown to inhibit specific key factors of the VEGF/VEGFR2 angiogenesis signaling pathway like matrix metalloproteinase-9, c-JUN, interferon- g, and chemokines (C-X-C motif) [161]

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However, the N-terminus of Pls carries neither a condensation domain (C domain) nor a thioesterase domain (TE domain), as found in typical NRPSs, but instead harbors three tandem domains (C1-C3) related to acetyltransferase functions and six transmembrane domains (TM1-TM6) (Figure 2) (Kito et al., 2013

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