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doi: 10.1016/j.ejmech.2021.113825 84 BotsMJohnstoneRW

Journal of Biological Chemistry 262, 1987

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Interestingly, they found that roxadustat markedly alleviated kidney fibrosis and enhanced renal vascular regeneration and redox balance, possibly by activating the HIF-1/VEGF-A/VEGF receptor 1 signalling pathway and driving the expression of the endogenous antioxidant superoxide dismutase 2
The update is a step in the right direction for Novos candidate, which has previously been dinged by tolerability concerns in prior readouts
