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Upregulation of HLADR, intercellular adhesion molecule-1 and E-selectin activates CD2+, CD3+, CD5+, CLA+, CD45RO, HLA-DR, CD25 (IL-2 receptor) and CD27 expressing T cells [2]

Decrease of Cav-1 binding released the eNOS and subsequently enhanced the activation of eNOS

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By improving the absorption of B vitamins and minerals involved in cellular energy production, shilajit helps optimize the body's ability to convert nutrients into usable energy

Moreover, it supports detoxification by binding with heavy metals and promoting their elimination

Key transcription factors that regulate the expression of these genes include NF-E2 related factor 2 (Nrf2) via the antioxidant response element (ARE), AP-1, and nuclear factor kappa B (NFB)