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The presence of IR and signs of systemic low-grade inflammation are often associated with adverse prognosis in cancer [866]

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Chemical conjugation of epothilone with glutathione was studied, displaying a noticeable increasing of its anticancer activity towards various tumor cells [75], however, using several chemicals as cross-linkers for orienting the reaction, and checking the progress of reaction, and extra steps for purifying the conjugate is the major challenge

While promising, the doses required for sublingual delivery and the optimal formulation remain less established than injectable protocols

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Wound Repair and Regeneration, 2015, 23(1): 113