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P21 has similarly shown the ability to reverse dendritic and synaptic density loss caused by traumatic brain injury, restoring the physical architecture of neural connections that had been damaged

Tap water may contain impurities or bacteria that could compromise the sterility of the HCG solution and increase the risk of contamination or infection

This form can be used directly in the body, without need for conversion, and is better utilised than cyanocobalamin (5)

Injection Therapy Outcomes Research indicates B12 injections rapidly restore serum levels and reverse neurological symptoms in most patients

Due to the feasibility, we focused on CPs caused by mutations in epigenetic writers, which constitute the biggest group of CPs and have been most characterized in terms of immunopathology ( Figure 1 ) ( Figure 1 2 Methods 2.1 Registration This systematic review was registered in the INPLASY database (registration number: INPLASY2025120066) and is reported in accordance with PRISMA 2020 guidelines