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The UPR regulates mitochondrial activity at several levels, including enhancing mitochondrial protein quality control, augmenting ER-mitochondrial interactions and calcium signaling, and contributing to mitochondrial depolarization and initiation of apoptosis (Fan and Simmen, 2019, Gutierrez and Simmen, 2018, Rainbolt et al., 2014)

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GHK-Cu is a naturally occurring copper-binding peptide first discovered in human plasma

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Altuntas C, Demiralay M, Muslu AS, Terzi R (2020) Proline-stimulated signaling primarily targets the chlorophyll degradation pathway and photosynthesis associated processes to cope with short-term water deficit in maize