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The cyclization of terpene synthases (TPs) with further alterations and modifications, such as acylation, glycosylation, and oxidation, leads to the formation of sesterterpenes

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In addition, genetic factors such as the APOE genotype influence not only astrocyte metabolism but also their propensity to become reactive
SARM1 deletion restrains NAFLD induced by high fat diet (HFD) through reducing inflammation, oxidative stress and lipid accumulation

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Together, these two mechanisms explain why low-dose atropine can paradoxically enhance vagal effects and slow sinoatrial node firing before higher doses shift the balance toward the expected anticholinergic tachycardia
