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If dietary sources arent sufficient, vitamin B12 supplements, available in various forms, can help fill the gap just ensure to consult a healthcare professional beforehand

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In addition to SAM depletion, even inactive NNMT can interact with betaine-homocysteine methyltransferase (BHMT), methionine adenosyltransferase (MAT), and adenosylhomocysteinase (AHCY) to regulate methyl donor balance (96, 97)

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