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Deciphering the molecular pathways of saroglitazar: a dual PPAR/ agonist for managing metabolic NAFLD

Concurrently, ROS activate immune cells and stimulate lipid mediator generation, establishing a self-perpetuating inflammation loop through NF-B/JAK-STAT signaling [402]

A great deal of chronic disorders can be brought on by the body's overproduction of free radicals, which can also cause the body to break down important macromolecules like DNA, lipids, and proteins (Serafini et al., 2006)