perianal melanotic macule macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Oral Melanotic Macule: Symptoms and
Description
2018 Sep;110(4):570-577
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Author Affiliations: Bayhealth Medical Center, Dover, Delaware (DeSimone, Zaragoza)
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase, C
PH domain and C2 domain) that display affinity for different phospholipid components of the plasma membrane
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