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It is, therefore, critical that detoxification happens within the brain cells

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This Fc domain serves a dual function: it sterically hinders access to DPP-4, thereby protecting the GLP-1 moiety from enzymatic degradation, and it engages the neonatal Fc receptor (FcRn), facilitating receptor-mediated recycling and preventing lysosomal degradation following cellular uptake

The treatment also led to improvements in waist circumference, waist-to-hip ratio, and body image, without affecting blood sugar levels or causing major side effects

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doi: 10.1186/s12967-020-02506-6 [DOI] [PMC free article] [PubMed] [Google Scholar] 588