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10.1136/gutjnl-2022-327599 92 MengJ.GaoS
If needed for a clear medical indication (such as treating pellagra in a pregnant patient), niacinamide can be used with caution, but unnecessary high-dose B supplementation is avoided in pregnancy

Apparently, one of the reasons for this change was to align the Japanese cards with the international ones

PE-22-28: PE-22-28 has limited safety data from preclinical studies

In fact, the largest weight loss trials for all three medications were conducted in people without diabetes
