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These complex interactions of TNF- with numerous pathways imply that modulating this cytokine could yield synergistic protective benefits in ischemia-reperfusion injury 21

Thus, targeting PKM2 and its corresponding oncogenic post-translational modifications may be a promising clue for TNBC treatments

To address the urgent need for effective lungtargeted therapies, strategies that maximize local therapeutic efficacy while minimizing systemic toxicity are essential to the unique anatomical location of the lungs, inhaled therapy provides a promising strategy for locally targeted drug delivery through intranasal or intratracheal administration

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