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This cell death mechanism is now receiving widespread attention, extending well beyond its original identification in cancer research, including in the field of drug-induced liver injury

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As a statement made by one of the leaders in vitamin B12 field more than 10 years ago, Carmels idea of cobalamin deficiency should not be diagnosed unless megaloblastic changes are found is still followed by many physicians and health authorities when accepting B12 deficiency diagnosis.1 But as time goes by, evidence and clinical cases []

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