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[2] This combination approach, sometimes termed triple therapy (hydroquinone + retinoid + steroid), is a well-recognized strategy in melasma treatment and has been shown to produce superior outcomes compared to any of the individual components alone

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doi: 10.1007/s00216-004-2624-z

Age and dose related sensitivity in 2-butoxyethanol f344 rat model of hemolytic anemia and disseminated thrombosis

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Pei L, Che R, He L