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However, due to the instability and high reactive activity of Fe 2+ , many intracellular pathways can alter cells sensitivity to ferroptosis by changing the intracellular Fe 2+ levels

For those reasons, we stated that we believed that the most appropriate fixed-loss amount for site neutral payment rate cases for FYs 2016 through 2023 would be equal to the IPPS fixed-loss amount for that particular fiscal year