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Reactive astrocytes might be also involved the neuroinflammation and the BBB dysfunction, as observed in multiple sclerosis and experimental autoimmune encephalomyelitis [117, 118]

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Wang F, Liu X, Huang F, et al: Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury through inhibiting ferroptosis

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Oxidative stress in developmental brain disorders

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In an effort to reach target tissues of the sinuses and central nervous system (CNS), glutathione is being prescribed as an intranasal spray, although no literature exists to support this mode of administration

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Besides, AD development may be prevented using moisturizers and probiotics with a high probability in infants

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Whitehead M, Osborne A, Widdowson PS et al (2019) Angiopoietins in diabetic retinopathy: current understanding and therapeutic potential

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