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Preclinical in vivo evidence: energy expenditure, substrate selection, and adiposity In chow-fed mice kept at thermoneutrality, repeated SLU-PP-332 administration increases energy expenditure, lowers RER (favoring fat over carbohydrate oxidation), and reduces adipocyte size, without changing food intake or spontaneous locomotor activity

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Likely due to partial coverage of the viral vector expression, this targeted genetic manipulation resulted in a 55 10% reduction in Drd1a mRNA in the dorsal striatum, with no significant change observed in the ventral striatum (Fig

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