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doi: 10.1016/j.cmet.2015.02.002 72 KangPJZhengJLeeGSonDKimIYSongGet al

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Consistent with our findings, studies with mouse aortic endothelial cells isolated from GPx1 / and wildtype mice reported that GPx1-deficiency promotes ROS production (both superoxide and hydrogen peroxide), enhances MAPK and NFB activation, and upregulates VCAM1 expression in response to TNF [85]

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