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Semaglutide: The GLP-1 Pathway Semaglutide is a GLP-1 receptor agonist with 94% homology to native GLP-1 and a ~7-day half-life achieved through C18 fatty acid acylation and DPP-4 resistance (Muller et al., 2021)
Interestingly, researchers observed that the speed of titration directly correlated with the frequency of transient side effects, but not necessarily with the ultimate efficacy at week 48
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Halogenation is often a bioactivity conferring modification for polyketide and alkaloid natural products [6, 7]
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