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Concretely, Sirt1 promoted mitochondrial biogenesis and function by deacetylating peroxisome proliferator-activated receptor gamma coactivator 1- (PGC-1), enhanced lipophagy and reduced lipid accumulation through the deacetylation of forkhead box O3a (FoxO3a) in HFD-induced MASLD mice model [18]
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