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Upon delivery, it was reported that the peptide appeared to induce a slight increment in levels of blood glucose and lactate, with a slight reduction in the ratio of glycogen synthase in muscle, adipose tissues, and the liver
OLeary NA, Wright MW, Brister JR et al (2016) Reference sequence (RefSeq) database at NCBI: current status, taxonomic expansion, and functional annotation
Additionally, mice and rats have been observed to transfer AX to various tissues, including adipose tissue, liver, skeletal muscle, brain, and others [250,326]
Through promotion of kynurenine accumulation, Tregs induce indoleamine 2,3-dioxygenase (IDO) expression in dendritic cells, which results in tryptophan depletion and immunosuppression, as kynurenine enhances Treg proliferation and suppresses Teff cells [25, 27]
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Br Med J 330:223226 Emmendoerffer A, Hecht M, Boeker T, Mueller M, Heinrich U (2000) Role of inflammation in chemical-induced lung cancer
