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During tumor immunotherapy, IFN- released by activated CD8 + T cells also upregulates the expression of ACSL4 in tumor cells through the STAT1-IRF1 signaling pathway [111]
doi: 10.1007/s12011-015-0325-4
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The FDA cited concerns including potential heart-related adverse events in available safety data and the general Category 2 rationale of insufficient safety information for compounding
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