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The increased awareness of the nutritional value of seafood has led to a surge in its consumption, reaching a global average of 20.5 kg per capita in 2020 [32] and 20.7 kg per capita in 2022 [33], according to the Food and Agriculture Organization (FAO)

Mild irritation potential was noted for compounds like benzoic and glycolic acids at high concentrations, while palmitic acid may have metabolic implications, including lipid dysregulation and obesity risk (Saraswathi et al., 2020)

However, renal and liver toxicity remains a concern in clinical trials [214, 215]

The emergence of predominantly cognitive FTD-like phenotypes in the TDP-43 K408R mice is not unusual in TDP-43 knock in models such as TDP-43 Q331K and TDP-43 K145R mice which present with features of cognitive dysfunction but lacking the entire constellation of ALS/FTD-like phenotypes[45, 119]