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The concentrating capacity is dependent on the renal medulla.27 The degree of medullary concentration is established primordially by the renal tubules in the loop of Henle and the blood vessels surrounding it (vasa recta) during the countercurrent exchange process

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10.1007/s10072-014-2029-5 161 WangY.PatelR.RenC.TaggartM

Similarly, the BBB is estimated to be non-permeant to the compounds according to the SwissADME server estimation

T.Fernndez-VarnE.Torres-GarcaA.BlancasI.et al (2025)