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[5] Notably, normal feedback mechanisms remain intact: elevated IGF-1 and GH can signal the hypothalamus and pituitary to modulate further hormone release, which may reduce the risk of extreme hormone levels

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doi: 10.1097/AOG.0b013e3181a66843 174 Snchez-RodrguezMAZacaras-FloresMArronte-RosalesACorrea-MuozEMendoza-NezVM
