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Increased cellular protein S -glutathionylation sensitized hepatocytes to TNF hepatotoxicity Increased cellular glutathionylated protein levels in response to GSSG accumulation prompted us to examine the effects of cellular protein S -glutathionylation on TNF-induced cell death

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At the same time, endothelial cell senescence also affects the delivery of nutrients and oxygen, leading to metabolic abnormalities and further accelerating organismal aging (Boutouyrie et al., 2021