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Patients in the high-risk group exhibited down-regulated immune-effector pathways, elevated expression of the checkpoint molecules PD-L1 and LAG-3, and a trend toward an immune-evasive phenotype, suggesting potential resistance to immunotherapy

Lu J, Chen M, Tao Z, Gao S, Li Y, Cao Y, Lu C, Zou X (2017) Effects of targeting SLC1A5 on inhibiting gastric cancer growth and tumor development in vitro and in vivo

It is clear that once the gene expression of autoimmune disease turns on, there is no off switch, but there is a dimmer switch that can modulate how active the expression becomes

Internalized macropinosomes containing proteins are shuttled to and fuse with lysosomes and the proteins are degraded into their constituent amino acids