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Long-term exposure to these agents may elevate the risk of PD [27]

247 Increased fat mass, metabolic dysfunction, and systemic inflammatory responses are key features of these metabolic diseases and can further exacerbate immune dysfunction associated with aging

doi: 10.1056/EVIDoa2200008 43 BejarRPapaemmanuilEHaferlachTGarcia-ManeroGMaciejewskiJPSekeresMAet al

Interestingly, Chac1 expression is decreased in livers of patients with MASLD, highlighting its potential therapeutic relevance
