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FIGURE 1 2 The role of sleep in regulating free radicals in the brain: from Reimunds free radical flux theory to modern insights Reimunds free radical flux theory of sleep, proposed in the 1990s, received significant attention for suggesting that ROS accumulate in the brain during wakefulness, when energy consumption is high, and are subsequently cleared during sleep through a scavenging process that also suppresses their production (Reimund, 1994

The titration protocol exists for safety reasons that are independent of any co-administered compound

This enhances regenerative effect on the specific area

Nevertheless, loading it on hydrogels can result in slow drug release and effectively prevent the problem of rapid degradation [34,35]

Piracetam promotes mossy fiber synaptic reorganization in rats withdrawn from alcohol

One strong point of the study was the inclusion of genotype